Genomenon® Mastermind

Mastermind® by Genomenon® is a search engine with comprehensive collection of genomic evidence and a user-friendly database.
More information about Genomenon is available at https://www.genomenon.com/tutorials/

Mastermind visualization can be activated in the Options dialog box (menu 'Tools' > 'Preferences' > 'Display' tab)

Alamut® Visual displays Mastermind variants in a dedicated track: Mastermind Cited Variants Reference. Variants are reported from Cited Variants Reference (CVR), equivalent to a Variant Call Format (VCF) file.
The CVR contains a count of articles associated with each variant, along with a deep link into the related Mastermind UI. More information on CVR at https://www.genomenon.com/cvr/.

If multiple SNVs are reported at the same position, a "+" sign is displayed.
Right-click on a variant to access the Mastermind website.

Mouse over on a CVR variant to pop-up a tooltip displaying the HGVS field and the three MMCNT values:

• MMCNT1: cDNA-level exact matches
  The number of articles mentioning the variant at the nucleotide level in title/abstract or full-text.
• MMCNT2: cDNA-level possible matches
  The number of articles with nucleotide-level (from 1) and protein-level matching with not specified cDNA-level change (articles could refer to this nucleotide-level variant but there is insufficient data to determine conclusively).
• MMCNT3 : same biological effect matches
  The number of articles citing any variant with the same biological effect as the considered variant. This includes MMCNT1 and MMCNT2 articles plus those with alternative cDNA-level variants that result in the same protein effect.

A new field in the variant panel displays the number of articles, including the three MMCNT values, and the link to the Mastermind website.

Publications on a given variant referenced in Mastermind are mentioned in the variant report, with a link to the Mastermind website.